Description

2-Ethynyl-4-Fluoroaniline is a high-purity, multi-functional aromatic amine building block featuring both an ethynyl and a fluoro substituent. This compound is critical for advanced organic synthesis, enabling the construction of complex molecular architectures through cross-coupling and cycloaddition reactions. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and materials science sectors for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and fungicides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers, resins, and conductive organic materials.
• Ligand and Catalyst Development: Employed in the design of novel ligands for transition metal catalysis and organocatalysts.
• Fluorescent Probe and Dye Chemistry: Acts as a building block for synthesizing fluorophores and molecular sensors due to its aromatic amine and ethynyl groups.
• Academic and Contract Research: Essential for methodological development and exploratory synthesis in university and CRO laboratories.

Basic Information

Product Name	2-Ethynyl-4-Fluoroaniline
CAS No.	887903-03-9
Molecular Formula	C8H6FN
Molecular Weight	135.14 g/mol
Synonyms	4-Fluoro-2-ethynylaniline; 2-Amino-5-fluorophenylacetylene; 1-Amino-4-fluoro-2-ethynylbenzene; 4-Fluoro-2-ethynylbenzenamine; 2-Ethynyl-4-fluoro-benzenamine; 2-Ethynyl-4-fluoro-phenylamine; (4-Fluoro-2-aminophenyl)acetylene
EINECS	Contact for details

Quality Control

Our 2-Ethynyl-4-Fluoroaniline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC for residual solvent analysis, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Keep away from oxidizing agents and strong acids.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.