Description

Boc-Thr(Val-Fmoc)-OH is a protected dipeptide building block of significant importance in solid-phase peptide synthesis (SPPS). Its value lies in the orthogonal protection strategy, where the Boc (tert-butoxycarbonyl) group protects the N-terminus and the Fmoc (9-fluorenylmethoxycarbonyl) group protects the side chain of valine, allowing for selective deprotection and controlled chain elongation. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostics, and research biochemicals.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical intermediate for the controlled, sequential assembly of complex peptide sequences in both research and GMP manufacturing.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) for peptide drugs targeting metabolic disorders, oncology, and infectious diseases.
• Bioconjugation & Labeling: Serves as a precursor for creating peptide conjugates with reporter molecules, polymers, or other biomolecules for diagnostic and research applications.
• Combinatorial Chemistry Libraries: A key building block for generating diverse peptide libraries used in high-throughput screening for drug discovery.
• Academic & Institutional Research: Fundamental reagent for studying protein-protein interactions, enzyme substrates, and structure-activity relationships (SAR) in biochemistry and molecular biology labs.
• Custom Peptide Service Providers: A staple raw material for CROs and CDMOs offering bespoke peptide synthesis services to the global life science community.

Basic Information

Product Name	Boc-Thr(Val-Fmoc)-OH
CAS No.	887707-95-1
Molecular Formula	C30H38N2O8
Molecular Weight	554.64 g/mol
Synonyms	Boc-Thr(Val-Fmoc)-OH; N-[(1,1-Dimethylethoxy)carbonyl]-O-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-threonyl-L-valine; Boc-L-Threonine(Fmoc-L-valine); Boc-Thr(Val-Fmoc); tert-Butyloxycarbonyl-threonyl(valyl-9-fluorenylmethyloxycarbonyl) acid; Fmoc-Val-Thr(Boc)-OH (sequence notation); (2S,3R)-2-[[(2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-methylbutanoyl]amino]-3-[(2-methylpropan-2-yl)oxycarbonyloxy]butanoic acid (IUPAC); Boc-Thr(Fmoc-Val)-OH
EINECS	Contact for details

Quality Control

Our Boc-Thr(Val-Fmoc)-OH is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identity confirmation (IR, NMR, MS) to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment, supporting compliance in research and cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Assay	≥ 97.0%
Specific Rotation	-15° to -25° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.