Description

Fmoc-Homocys(Mmt)-Oh CAS NO 887644-62-4 is a protected amino acid derivative, specifically an Fmoc-homocysteine derivative with an Mmt (4-methoxytrityl) protecting group on the thiol side chain. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of homocysteine residues into complex peptide sequences. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and life sciences who require high-purity, specialized amino acids for synthesizing peptides with specific structural or functional properties.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled introduction of homocysteine into peptide chains.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including those targeting metabolic disorders or cardiovascular diseases.
• Bioconjugation and Protein Engineering: The protected thiol group allows for site-specific modifications, labeling, or cross-linking of peptides and proteins.
• Synthesis of Peptide Mimetics: Facilitates the creation of stable peptide analogs with modified backbone structures for enhanced bioavailability.
• Combinatorial Chemistry Libraries: Serves as a valuable building block for generating diverse peptide libraries for high-throughput screening.
• Academic and Industrial Research: Employed in studies investigating protein folding, disulfide bond formation, and redox biochemistry.

Basic Information

Product Name	Fmoc-Homocys(Mmt)-Oh
CAS No.	887644-62-4
Molecular Formula	C40H37NO5S
Molecular Weight	643.79 g/mol
Synonyms	Fmoc-Hcy(Mmt)-OH; Fmoc-L-homocysteine(Mmt)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-[(4-methoxyphenyl)diphenylmethyl]-L-homocysteine; N-α-Fmoc-S-Mmt-L-homocysteine; Fmoc-S-(4-Methoxytrityl)-L-homocysteine; Fmoc-Homocysteine(Mmt)-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-((4-methoxyphenyl)diphenylmethyl)thio)butanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Homocys(Mmt)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability, consistency, and compliance with research and cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0% (Area %)
Optical Rotation	-15.0° to -20.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.