Description

7-Bromo-4-Chloro-2-Trifluoromethyl-Quinazoline is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of halogen and trifluoromethyl substituents, which enables precise molecular modifications to fine-tune the properties of target compounds. This intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly kinase inhibitors and other biologically active molecules targeting various therapeutic areas.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the quinazoline scaffold and halogen atoms contribute to bioactivity.
• Material Science: Serves as a building block for creating advanced organic electronic materials, such as OLED (Organic Light-Emitting Diode) components, due to its electron-deficient aromatic structure.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitutions, leveraging the reactive bromo and chloro sites for further functionalization.
• Ligand & Catalyst Development: Utilized to construct complex nitrogen-containing ligands for metal catalysis and coordination chemistry.

Basic Information

Product Name	7-Bromo-4-Chloro-2-Trifluoromethyl-Quinazoline
CAS No.	887592-32-7
Molecular Formula	C9H3BrClF3N2
Molecular Weight	311.48 g/mol
Synonyms	7-Bromo-4-chloro-2-(trifluoromethyl)quinazoline; 2-(Trifluoromethyl)-7-bromo-4-chloroquinazoline; 4-Chloro-7-bromo-2-trifluoromethylquinazoline; Quinazoline, 7-bromo-4-chloro-2-(trifluoromethyl)-; 887592-32-7; BCTQ
EINECS	Contact for details

Quality Control

Our 7-Bromo-4-Chloro-2-Trifluoromethyl-Quinazoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.