Description

Quinazoline, 6-Bromo-4-Chloro-2-(1,1-Dimethylethyl)- is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. This compound is valued for its role as a key intermediate in the development of novel pharmaceutical agents and agrochemicals, where its unique halogenated and substituted quinazoline core enables precise molecular modifications. It is primarily sought by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating targeted bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of kinase inhibitors, anticancer agents, and other small-molecule drug candidates targeting specific biological pathways.
• Agrochemical Research: Serves as a foundational scaffold for developing new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Used in the research and development of organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient aromatic system.
• Chemical Biology & Proteomics: Employed as a molecular probe or a tag in the study of enzyme function and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical companies for custom synthesis projects requiring high-purity, complex heterocycles.
• Academic & Institutional Research: Utilized in university and government laboratories for fundamental studies in organic chemistry and medicinal chemistry.

Basic Information

Product Name	Quinazoline, 6-Bromo-4-Chloro-2-(1,1-Dimethylethyl)-
CAS No.	887592-20-3
Molecular Formula	C₁₂H₁₂BrClN₂
Molecular Weight	299.59 g/mol
Synonyms	6-Bromo-4-chloro-2-tert-butylquinazoline; 2-tert-Butyl-6-bromo-4-chloroquinazoline; 6-Bromo-4-chloro-2-(tert-butyl)quinazoline; 4-Chloro-6-bromo-2-tert-butylquinazoline; Quinazoline, 6-bromo-4-chloro-2-(1,1-dimethylethyl)-; 2-(tert-Butyl)-6-bromo-4-chloroquinazoline; 6-Bromo-4-chloro-2-(2-methyl-2-propanyl)quinazoline
EINECS	Contact for details

Quality Control

Our Quinazoline, 6-Bromo-4-Chloro-2-(1,1-Dimethylethyl)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.