Description

3,4-Difluoro-5-Hydroxybenzaldehyde is a versatile fluorinated aromatic aldehyde building block of significant interest in advanced organic synthesis. Its unique structure, featuring both aldehyde and phenolic hydroxyl groups on a difluorinated benzene ring, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where the introduction of fluorine atoms is a key strategy to modulate bioactivity, metabolic stability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) active compounds where the difluoro-hydroxybenzaldehyde scaffold is integral.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and pesticides, leveraging fluorine's ability to enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated aromatic cores in advanced electronic materials, contributing to improved performance in displays and lighting.
• Polymer Modification: Acts as a monomer or cross-linking agent for introducing fluorine and reactive aldehyde groups into specialty polymers, enhancing chemical resistance and surface properties.
• Complex Ligand Synthesis: Employed in the preparation of fluorinated ligands for catalysis and metal-organic frameworks (MOFs), enabling fine-tuning of electronic and steric properties.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D focused on fluorination chemistry, heterocyclic synthesis, and the exploration of new chemical entities.

Basic Information

Product Name	3,4-Difluoro-5-Hydroxybenzaldehyde
CAS No.	887584-91-0
Molecular Formula	C7H4F2O2
Molecular Weight	158.10 g/mol
Synonyms	5-Hydroxy-3,4-difluorobenzaldehyde; 3,4-Difluoro-5-hydroxybenzenecarboxaldehyde; 3,4-Difluoro-5-hydroxy-benzaldehyde; Benzaldehyde, 3,4-difluoro-5-hydroxy-; 5-Hydroxy-3,4-difluorobenzaldehyde (CAS 887584-91-0)
EINECS	Contact for details

Quality Control

Our 3,4-Difluoro-5-Hydroxybenzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong bases, and reducing agents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.