Description

3-(2-Fluoro-Phenylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-value, fluorinated pyrrolidine derivative serving as a critical building block in advanced organic synthesis. Its core value lies in providing a protected amine and carboxylic acid functionality, enabling the efficient construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of drug candidates, especially those targeting central nervous system (CNS) disorders, due to the pyrrolidine scaffold and fluorine moiety.
• Agrochemical Research: Used in developing new pesticides and herbicides, where the fluorine atom can enhance biological activity and metabolic stability.
• Peptidomimetics & PROTACs: Serves as a versatile component for constructing peptide mimics and proteolysis-targeting chimeras (PROTACs) for drug discovery.
• Ligand & Catalyst Development: Employed in creating novel chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Useful for synthesizing labeled compounds and probes to study biological pathways and enzyme function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific fluorinated intermediates.

Basic Information

Product Name	3-(2-Fluoro-Phenylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	887578-54-3
Molecular Formula	C15H21FN2O2
Molecular Weight	280.34 g/mol
Synonyms	1-Boc-3-((2-fluorophenyl)amino)pyrrolidine; tert-Butyl 3-[(2-fluorophenyl)amino]pyrrolidine-1-carboxylate; 3-[(2-Fluorophenyl)amino]-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester; 3-(2-Fluoroanilino)pyrrolidine-1-carboxylic Acid tert-Butyl Ester; 1-(tert-Butoxycarbonyl)-3-((2-fluorophenyl)amino)pyrrolidine; N-(2-Fluorophenyl)-1-Boc-3-aminopyrrolidine; 887578-54-3; 3-(2-Fluoro-Phenylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our 3-(2-Fluoro-Phenylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP, ICH Q7, and other relevant pharmaceutical guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from strong acids and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.