Description

4-Chloro-5-Fluoro-2-Phenylpyrimidine is a high-value halogenated pyrimidine building block essential for modern synthetic chemistry. This compound matters because it serves as a critical intermediate in the development of advanced pharmaceutical agents and agrochemicals, enabling the introduction of specific halogen functionalities that modulate biological activity. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its halogenated pyrimidine core.
• Material Science Precursor: Serves as a building block for organic electronic materials and liquid crystals.
• Chemical Biology Probe Development: Utilized in creating tool compounds for target validation and biochemical pathway studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and complex molecules.
• Academic & Industrial R&D: Employed in exploratory chemistry for novel heterocyclic compound libraries.

Basic Information

Product Name	4-Chloro-5-Fluoro-2-Phenylpyrimidine
CAS No.	887571-35-9
Molecular Formula	C10H6ClFN2
Molecular Weight	208.62 g/mol
Synonyms	2-Phenyl-4-chloro-5-fluoropyrimidine; 4-Chloro-5-fluoro-2-phenyl-pyrimidine; 5-Fluoro-4-chloro-2-phenylpyrimidine; 887571-35-9; 4-Chloro-5-fluoro-2-phenylpyrimidine; 2-Phenyl-5-fluoro-4-chloropyrimidine; 4-Chloro-5-fluoro-2-phenyl-1,3-diazine
EINECS	Contact for details

Quality Control

Our 4-Chloro-5-Fluoro-2-Phenylpyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.