Description

4-[(5-Bromopyrimidin-2-Yl)Oxy]Benzonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its bromopyrimidine and benzonitrile functional groups. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of kinase inhibitors and other targeted cancer therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Agrochemical Development: Serves as a precursor in the research and synthesis of novel herbicides and fungicides.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule construction.
• Academic Research: Used in university and institutional labs for fundamental research in heterocyclic and organic chemistry.

Basic Information

Product Name	4-[(5-Bromopyrimidin-2-Yl)Oxy]Benzonitrile
CAS No.	887430-98-0
Molecular Formula	C11H6BrN3O
Molecular Weight	276.09 g/mol
Synonyms	4-[(5-Bromopyrimidin-2-yl)oxy]benzonitrile; 5-Bromo-2-(4-cyanophenoxy)pyrimidine; Benzonitrile, 4-[(5-bromo-2-pyrimidinyl)oxy]-; 2-(4-Cyanophenoxy)-5-bromopyrimidine; 4-(5-Bromopyrimidin-2-yloxy)benzonitrile; 5-Bromo-2-(4-cyanophenoxy)pyrimidine; 4-(5-Brom-2-pyrimidinyloxy)benzonitril
EINECS	Contact for details

Quality Control

Our 4-[(5-Bromopyrimidin-2-Yl)Oxy]Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP guidelines for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.