Description

2-(3-Bromo-2,6-Difluorophenyl)-1,3-Dioxalane is a high-purity, specialized organic intermediate featuring a unique halogenated aromatic structure. This compound is valued for its role as a critical building block in advanced synthetic chemistry, enabling the development of complex molecules with precision. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders or possessing fluorinated bioactive motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluorophenyl moiety can enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination, facilitating complex bond formation.
• Fluorine Chemistry Studies: An important compound for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in medicinal and agrochemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	2-(3-Bromo-2,6-Difluorophenyl)-1,3-Dioxalane
CAS No.	887268-17-9
Molecular Formula	C9H7BrF2O2
Molecular Weight	265.05 g/mol
Synonyms	1,3-Dioxolane, 2-(3-bromo-2,6-difluorophenyl)-; 3-Bromo-2,6-difluorobenzaldehyde ethylene acetal; 2-(3-Bromo-2,6-difluorophenyl)-1,3-dioxolane; (3-Bromo-2,6-difluorophenyl)-1,3-dioxolane; Benzaldehyde, 3-bromo-2,6-difluoro-, ethylene acetal
EINECS	Contact for details

Quality Control

Every batch of 2-(3-Bromo-2,6-Difluorophenyl)-1,3-Dioxalane is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request. We adhere to cGMP guidelines where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.