Description

Ethyl 7-Amino-2-Methyl-3-[3-(Trifluoromethyl)Phenyl]Pyrazolo[1,5-A]Pyrimidine-6-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within oncology and other specialized drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting kinase inhibition.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• API Development: Integral in the process development and scale-up of new active pharmaceutical ingredients for clinical trials and commercial manufacturing.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs supporting global drug discovery and development programs.
• Biochemical Reagent: May be utilized in biochemical assays as a reference standard or probe compound for target validation.

Basic Information

Product Name	Ethyl 7-Amino-2-Methyl-3-[3-(Trifluoromethyl)Phenyl]Pyrazolo[1,5-A]Pyrimidine-6-Carboxylate
CAS No.	886762-57-8
Molecular Formula	C₁₇H₁₅F₃N₄O₂
Molecular Weight	364.32 g/mol
Synonyms	7-Amino-2-methyl-3-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-6-carboxylic acid ethyl ester; Ethyl 7-amino-2-methyl-3-(3-trifluoromethylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxylate; 886762-57-8; Pyrazolo[1,5-a]pyrimidine-6-carboxylate derivative; CAS 886762-57-8; 3-(3-(Trifluoromethyl)phenyl)-7-amino-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our production of Ethyl 7-Amino-2-Methyl-3-[3-(Trifluoromethyl)Phenyl]Pyrazolo[1,5-A]Pyrimidine-6-Carboxylate adheres to stringent quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical R&D. All materials are subjected to rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.