Description

4-Fluoro-3-(Trifluoromethoxy)Phenol is a high-purity fluorinated phenolic compound, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in its unique trifluoromethoxy and fluorine substituents, which are instrumental in modulating the physicochemical properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors, particularly for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs), especially in the development of fluorinated drug candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethoxy groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated monomers used in high-performance liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs) to improve thermal stability and electro-optical properties.
• Polymer & Resin Modification: Incorporated as a functional monomer to create specialty polymers with enhanced chemical resistance, lower dielectric constants, and improved weatherability for coatings and electronic encapsulants.
• Chemical Research & Development: A versatile reagent for medicinal chemistry and material science R&D, enabling structure-activity relationship (SAR) studies and the exploration of novel fluorinated architectures.

Basic Information

Product Name	4-Fluoro-3-(Trifluoromethoxy)Phenol
CAS No.	886501-26-4
Molecular Formula	C7H4F4O2
Molecular Weight	196.10 g/mol
Synonyms	3-(Trifluoromethoxy)-4-fluorophenol; 4-Fluoro-3-trifluoromethoxyphenol; 4-Fluoro-α,α,α-trifluoro-m-cresol; 1-Hydroxy-4-fluoro-3-(trifluoromethoxy)benzene; Phenol, 4-fluoro-3-(trifluoromethoxy)-; F3CO-Ph-F-OH (abbrev.)
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-(Trifluoromethoxy)Phenol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up processes. Certificates of Analysis (COA) with full traceability are provided for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive and should be stored away from direct light exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.