Description

4-Chloro-3-(Trifluoromethoxy)Phenol is a high-value fluorinated phenolic intermediate with a unique combination of halogen and alkoxy substituents. This compound matters for its role in synthesizing advanced agrochemicals and pharmaceuticals, where its structure imparts desirable biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the agrochemical, pharmaceutical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Agrochemical Intermediate: A key building block for the synthesis of novel herbicides, fungicides, and insecticides, leveraging the trifluoromethoxy group for enhanced lipophilicity and bioactivity.
• Pharmaceutical Synthesis: Serves as a versatile precursor in medicinal chemistry for developing active pharmaceutical ingredients (APIs), particularly in candidates targeting central nervous system (CNS) disorders.
• Liquid Crystal & OLED Materials: Used in the research and production of advanced electronic materials, where its polarizable structure contributes to desired electro-optical properties.
• Polymer Modification: Acts as a functional monomer or additive to introduce specific halogenated and fluorinated characteristics into polymer chains, enhancing material properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl structures.

Basic Information

Product Name	4-Chloro-3-(Trifluoromethoxy)Phenol
CAS No.	886500-85-2
Molecular Formula	C7H4ClF3O2
Molecular Weight	212.55 g/mol
Synonyms	4-Chloro-3-(trifluoromethoxy)phenol; 3-Trifluoromethoxy-4-chlorophenol; 4-Chloro-alpha,alpha,α-trifluoro-m-cresol; 1-Chloro-2-hydroxy-5-(trifluoromethoxy)benzene; Phenol, 4-chloro-3-(trifluoromethoxy)-; 886500-85-2; 4-Chloro-3-trifluoromethoxyphenol
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-(Trifluoromethoxy)Phenol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP, ISO, and REACH standards for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.