Description

4,5-Difluoro-2-Methoxybenzyl Bromide is a high-value, multi-functional organic building block. This compound is essential for the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where its difluoromethoxybenzyl motif is a key structural element. It is primarily sought after by R&D chemists and process development scientists for creating active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used to construct advanced herbicide and pesticide molecules, leveraging the stability imparted by the fluorine atoms.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and material science.
• Fluorinated Liquid Crystal Research: Employed in the development of fluorinated aromatic cores for advanced display materials.
• Organic Electronic Materials: Acts as a building block for electron-deficient aromatic units in organic semiconductors.
• Custom Synthesis & Contract Manufacturing: A key reagent for CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	4,5-Difluoro-2-Methoxybenzyl Bromide
CAS No.	886499-64-5
Molecular Formula	C9H7BrF2O
Molecular Weight	249.05 g/mol
Synonyms	2-(Bromomethyl)-1,4-difluoro-5-methoxybenzene; 1-(Bromomethyl)-2,3-difluoro-6-methoxybenzene; 4,5-Difluoro-2-methoxybenzyl bromide; 2-Methoxy-4,5-difluorobenzyl bromide; (4,5-Difluoro-2-methoxyphenyl)methyl bromide; α-Bromo-4,5-difluoro-2-methoxytoluene
EINECS	Contact for details

Quality Control

Our 4,5-Difluoro-2-Methoxybenzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC/GC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.