Description

4-Chloro-3-(Trifluoromethoxy)Benzaldehyde is a high-purity, multi-functional aromatic aldehyde building block of significant importance in advanced organic synthesis. Its unique molecular structure, featuring both chloro and trifluoromethoxy substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of advanced organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge-transport molecules.
• Fluorine Chemistry Building Block: Essential for introducing the trifluoromethoxy group into complex molecular architectures, a sought-after moiety in medicinal and agrochemistry for its lipophilicity and metabolic stability.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	4-Chloro-3-(Trifluoromethoxy)Benzaldehyde
CAS No.	886499-59-8
Molecular Formula	C8H4ClF3O2
Molecular Weight	224.56 g/mol
Synonyms	4-Chloro-3-(trifluoromethoxy)benzaldehyde; 4-Chloro-alpha,alpha,α-trifluoro-m-anisaldehyde; 3-Trifluoromethoxy-4-chlorobenzaldehyde; 4-Chloro-3-trifluoromethoxybenzaldehyde; Benzaldehyde, 4-chloro-3-(trifluoromethoxy)-; 886499-59-8; 4-Chloro-α,α,α-trifluoro-m-anisaldehyde
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-(Trifluoromethoxy)Benzaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and reducing agents. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.