Description

2,4-Difluoro-3-Methoxybenzyl Bromide is a high-purity, multi-functional benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of fluorine and methoxy substituents on the aromatic ring, which enables precise modulation of electronic and steric properties in target molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality intermediates for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of active pharmaceutical ingredients (APIs), particularly in the development of fluorine-containing drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in constructing novel herbicides, fungicides, and insecticides where the difluoro-methoxy motif enhances biological activity, metabolic stability, and lipophilicity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-based molecules used in electronic displays and organic light-emitting diodes, where fluorine atoms improve charge transport and environmental stability.
• Cross-Coupling Reactions: The benzyl bromide moiety acts as an effective electrophile in various metal-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form new carbon-carbon bonds.
• Ligand & Catalyst Development: Employed in the synthesis of specialized phosphine or nitrogen-based ligands for asymmetric catalysis and transition metal complexes.
• Polymer & Resin Modifier: Incorporated as a functional monomer to introduce fluorine groups into polymers, altering their surface properties, chemical resistance, and durability.

Basic Information

Product Name	2,4-Difluoro-3-Methoxybenzyl Bromide
CAS No.	886499-17-8
Molecular Formula	C8H7BrF2O
Molecular Weight	237.04 g/mol
Synonyms	1-(Bromomethyl)-2,4-difluoro-3-methoxybenzene; (2,4-Difluoro-3-methoxyphenyl)methyl Bromide; 3-Methoxy-2,4-difluorobenzyl Bromide; α-Bromo-2,4-difluoro-3-methoxytoluene; 2,4-Difluoro-3-methoxybenzylbromide; 886499-17-8; Benzene, 1-(bromomethyl)-2,4-difluoro-3-methoxy-
EINECS	Contact for details

Quality Control

Every batch of 2,4-Difluoro-3-Methoxybenzyl Bromide is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.