Description

3-Fluoro-4-(trifluoromethoxy)benzylamine is a high-purity, multi-functional aromatic amine building block featuring both fluorine and trifluoromethoxy substituents. This compound is valued for its role in modulating the physicochemical properties of target molecules, offering enhanced metabolic stability, lipophilicity, and bioavailability. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorine motifs improve efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing compounds used in electronic display technologies and organic light-emitting diodes.
• Polymer & Material Science: Employed in the synthesis of specialty polymers, coatings, and advanced materials requiring specific thermal and chemical resistance.
• Chemical Research & Development: A versatile reagent for medicinal chemistry, facilitating structure-activity relationship (SAR) studies and lead optimization.
• Fluorinated Surfactant Precursor: Can be utilized in the development of specialty surfactants and surface-active agents with unique properties.

Basic Information

Product Name	3-Fluoro-4-(trifluoromethoxy)benzylamine
CAS No.	886499-13-4
Molecular Formula	C8H7F4NO
Molecular Weight	209.14 g/mol
Synonyms	(3-Fluoro-4-(trifluoromethoxy)phenyl)methanamine; 1-(3-Fluoro-4-(trifluoromethoxy)phenyl)methanamine; 3-Fluoro-4-(trifluoromethoxy)benzenemethanamine; 4-(Aminomethyl)-2-fluoro-1-(trifluoromethoxy)benzene; α-Amino-3-fluoro-4-(trifluoromethoxy)toluene; 3-Fluoro-4-trifluoromethoxybenzylamine; F-TFMO-Bn-NH2
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-(trifluoromethoxy)benzylamine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.