Description

5-[Ethyl-(2,2,2-Trifluoro-Acetyl)-Amino]-Naphthalene-1-Sulfonyl Chloride is a high-purity, specialized organic intermediate featuring a reactive sulfonyl chloride group and a trifluoroacetyl-protected amine. This compound matters for its role as a critical building block in the synthesis of complex molecules, particularly in advanced pharmaceutical research and fine chemical manufacturing. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel sulfonamide derivatives and fluorinated compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing sulfonamide moieties for therapeutic applications.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides where the sulfonyl chloride group enables the introduction of specific bioactive functionalities.
• Fluorinated Compound Synthesis: Serves as a valuable source of the trifluoroacetyl group for introducing fluorine atoms into target molecules, enhancing their metabolic stability and lipophilicity.
• Dye and Pigment Chemistry: Intermediate for creating specialized naphthalene-based dyes and functional colorants.
• Material Science: Building block for synthesizing monomers or additives used in advanced polymers and specialty materials.
• Bioconjugation and Probe Development: The reactive sulfonyl chloride allows for labeling and modifying biomolecules in biochemical research.

Basic Information

Product Name	5-[Ethyl-(2,2,2-Trifluoro-Acetyl)-Amino]-Naphthalene-1-Sulfonyl Chloride
CAS No.	886496-53-3
Molecular Formula	C₁₄H₁₁ClF₃NO₃S
Molecular Weight	365.75 g/mol
Synonyms	5-[(Ethyl)(2,2,2-trifluoroacetyl)amino]naphthalene-1-sulfonyl chloride; N-Ethyl-N-(2,2,2-trifluoroacetyl)-1-naphthalenesulfonamide chloride; 1-Naphthalenesulfonyl chloride, 5-[(ethyl)(trifluoroacetyl)amino]-; 5-(N-Ethyl-2,2,2-trifluoroacetamido)naphthalene-1-sulfonyl chloride; ETFA-Naphthalene Sulfonyl Chloride; N-Ethyltrifluoroacetamide naphthalene sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 5-[Ethyl-(2,2,2-Trifluoro-Acetyl)-Amino]-Naphthalene-1-Sulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.