Description

2,2,2-Trifluoro-1-(3-Fluoro-4-Methoxy-Phenyl)-Ethylamine is a high-purity fluorinated aromatic amine building block of significant interest in advanced organic synthesis. Its value lies in its unique trifluoroethylamine moiety attached to a substituted phenyl ring, which is crucial for modulating the physicochemical and metabolic properties of target molecules. This compound is primarily needed by pharmaceutical R&D and agrochemical manufacturers for the development of novel active ingredients, where its fluorine atoms are leveraged to enhance potency, stability, and bioavailability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in CNS and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the fluorine atoms contribute to improved environmental stability and target specificity.
• Ligand & Catalyst Development: Serves as a precursor for sophisticated ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic electronic materials due to its fluorinated structure.
• Fluorine Chemistry Library Building: An essential component for constructing diverse compound libraries in medicinal chemistry for high-throughput screening.

Basic Information

Product Name	2,2,2-Trifluoro-1-(3-Fluoro-4-Methoxy-Phenyl)-Ethylamine
CAS No.	886371-56-8
Molecular Formula	C9H9F4NO
Molecular Weight	223.17 g/mol
Synonyms	1-(3-Fluoro-4-methoxyphenyl)-2,2,2-trifluoroethanamine; α-(Trifluoromethyl)-3-fluoro-4-methoxybenzylamine; 3-Fluoro-4-methoxy-α-(trifluoromethyl)benzenemethanamine; 2,2,2-Trifluoro-1-(3-fluoro-4-methoxyphenyl)ethanamine; (R/S)-2,2,2-Trifluoro-1-(3-fluoro-4-methoxyphenyl)ethylamine; 886371-56-8; Benzenemethanamine, 3-fluoro-4-methoxy-α-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-(3-Fluoro-4-Methoxy-Phenyl)-Ethylamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.