Description

1-(3,5-Difluoro-Phenyl)-2,2,2-Trifluoro-Ethylamine is a high-value fluorinated aromatic amine building block. This compound is critical for introducing both difluorophenyl and trifluoroethylamine pharmacophores into advanced molecular structures. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its unique fluorine substitution pattern can significantly modulate biological activity, metabolic stability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in CNS, oncology, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where fluorine atoms enhance efficacy and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic electronic materials to alter surface properties and electronic characteristics.
• Diagnostic Reagent Precursor: Utilized in the development of fluorinated probes and contrast agents for imaging technologies.

Basic Information

Product Name	1-(3,5-Difluoro-Phenyl)-2,2,2-Trifluoro-Ethylamine
CAS No.	886369-65-9
Molecular Formula	C8H6F5N
Molecular Weight	211.13 g/mol
Synonyms	1-(3,5-Difluorophenyl)-2,2,2-trifluoroethanamine; 2,2,2-Trifluoro-1-(3,5-difluorophenyl)ethanamine; α-(Trifluoromethyl)-3,5-difluorobenzeneethanamine; 3,5-Difluoro-α-(trifluoromethyl)benzylamine; 886369-65-9; 1-(3,5-Difluorophenyl)-2,2,2-trifluoroethylamine; 2,2,2-Trifluoro-1-(3,5-difluorophenyl)ethylamine
EINECS	Contact for details

Quality Control

Our 1-(3,5-Difluoro-Phenyl)-2,2,2-Trifluoro-Ethylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. Certificates of Analysis (COA) documenting batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.