Description

4-(2,4-Difluorophenyl)Benzyl Alcohol is a high-purity fluorinated aromatic alcohol building block of significant interest in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of active pharmaceutical ingredients (APIs) and specialty materials, where the difluorophenyl moiety can impart desirable metabolic stability and binding properties. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and anti-inflammatory agent research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides where the fluorinated aromatic system enhances biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display and lighting materials.
• Polymer Modification: Employed to introduce fluorinated benzyl groups into polymer chains to alter surface properties and stability.
• Cross-Coupling Reactions: The benzyl alcohol group can be functionalized for use in Suzuki, Heck, or other palladium-catalyzed coupling reactions.
• Protecting Group Chemistry: Utilized in multi-step synthetic sequences where the alcohol functionality requires temporary protection and deprotection.

Basic Information

Product Name	4-(2,4-Difluorophenyl)Benzyl Alcohol
CAS No.	885963-33-7
Molecular Formula	C13H10F2O
Molecular Weight	220.22 g/mol
Synonyms	(4-(2,4-Difluorophenyl)phenyl)methanol; 1-(2,4-Difluorophenyl)-4-(hydroxymethyl)benzene; 2,4-Difluoro-4'-(hydroxymethyl)biphenyl; α-(2,4-Difluorophenyl)-p-tolylmethanol; p-(2,4-Difluorobenzyl)benzyl alcohol; 4-(2,4-Difluorophenyl)benzenemethanol
EINECS	Contact for details

Quality Control

Our 4-(2,4-Difluorophenyl)Benzyl Alcohol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤0.5% w/w
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.