Description

2,3,4,5,6-Pentafluorophenyl 2-Nitrobenzenesulfonate is a specialized fluorinated sulfonate ester, a high-value building block in advanced organic synthesis. This compound matters for its role as a versatile electrophilic reagent, enabling the efficient introduction of the pentafluorophenylsulfonyl (Pfp) group, a key moiety in the development of pharmaceuticals, agrochemicals, and functional materials. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing sulfonamide or sulfonate ester functionalities.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the pentafluorophenyl group enhances biological activity and stability.
• Material Science: Serves as a precursor for creating specialty polymers, liquid crystals, and advanced materials with unique surface properties.
• Proteomics & Bioconjugation: Employed in chemical biology for labeling proteins and peptides, leveraging its reactivity as an activating agent for amines and alcohols.
• Cross-Coupling Reactions: Acts as an electrophilic partner in palladium-catalyzed cross-coupling reactions to form carbon-sulfur and carbon-oxygen bonds.
• Chemical Derivatization: Utilized in analytical chemistry for derivatizing compounds to improve their detection via chromatography or mass spectrometry.

Basic Information

Product Name	2,3,4,5,6-Pentafluorophenyl 2-Nitrobenzenesulfonate
CAS No.	885950-33-4
Molecular Formula	C12H4F5NO5S
Molecular Weight	369.22 g/mol
Synonyms	Pentafluorophenyl 2-Nitrobenzenesulfonate; 2-Nitrobenzenesulfonic Acid Pentafluorophenyl Ester; Pentafluorophenyl o-Nitrobenzenesulfonate; 2,3,4,5,6-Pentafluorophenyl 2-Nitrobenzenesulphonate; PFP-ONs; Pentafluorophenyl 2-Nitrobenzene-1-sulfonate; 2-Nitrobenzenesulfonyl Pentafluorophenyl Ester; (Pentafluorophenyl) 2-nitrobenzene-1-sulfonate
EINECS	Contact for details

Quality Control

Our 2,3,4,5,6-Pentafluorophenyl 2-Nitrobenzenesulfonate undergoes rigorous quality testing to ensure compliance with industry standards for high-purity synthetic intermediates. Certificates of Analysis (COA) are available upon request, detailing parameters such as purity, identity, and impurity profiles. We adhere to strict in-process controls to guarantee batch-to-batch consistency and reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.