Description

4-Chloro-1-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine is a high-value heterocyclic building block and pharmaceutical intermediate of significant commercial interest. This compound is a key synthon in medicinal chemistry, particularly for the development of kinase inhibitors and other targeted therapeutic agents. It is essential for research and development laboratories, custom synthesis providers, and pharmaceutical manufacturers engaged in the creation of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of kinase inhibitors (e.g., JAK, BTK inhibitors) and other small molecule drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs for oncology, immunology, and inflammatory diseases.
• Biochemical Tool Compound: Serves as a core scaffold for developing chemical probes to study specific biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of Active Pharmaceutical Ingredients (APIs) and advanced intermediates.
• Academic Research: Utilized in university and institutional labs for exploratory synthetic chemistry and drug discovery projects.

Basic Information

Product Name	4-Chloro-1-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine
CAS No.	885524-07-2
Molecular Formula	C11H6ClFN4
Molecular Weight	248.64 g/mol
Synonyms	4-Chloro-1-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine; 1-(4-Fluorophenyl)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine; 4-Chloro-1-(p-fluorophenyl)pyrazolo[3,4-d]pyrimidine; 885524-07-2; Pyrazolo[3,4-d]pyrimidine, 4-chloro-1-(4-fluorophenyl)-; 4-Chloro-1-(4-fluorophenyl)-7H-pyrazolo[3,4-d]pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Chloro-1-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements of pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed in a well-ventilated area. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.