Description

Fmoc-Gln(Trt)-Ol CAS NO 885498-86-2 is a protected glutamine derivative widely used as a critical building block in solid-phase peptide synthesis (SPPS). Its primary value lies in enabling the controlled and efficient incorporation of glutamine into complex peptide sequences while preventing unwanted side reactions. This high-purity amino acid derivative is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences industries developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the Fmoc-strategy synthesis of peptides containing glutamine residues.
• Pharmaceutical R&D: Used in the research and development of novel peptide-based drugs, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation: Serves as a precursor for creating peptide-protein or peptide-small molecule conjugates for targeted therapies.
• Combinatorial Chemistry: Employed in the generation of peptide libraries for high-throughput screening and drug discovery.
• Proteomics Research: Utilized in the synthesis of defined peptide fragments for antibody production, epitope mapping, and protein interaction studies.
• Custom Peptide Services: A fundamental raw material for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Item	Details
Product Name	Fmoc-Gln(Trt)-Ol
CAS No.	885498-86-2
Molecular Formula	C39H36N2O5
Molecular Weight	612.72 g/mol
Synonyms	Fmoc-Gln(Trt)-ol; N-α-Fmoc-N-γ-trityl-L-glutamine; Fmoc-L-glutamine(trityl)-OH; N-(9-Fluorenylmethoxycarbonyl)-N'-trityl-L-glutamine; Fmoc-Gln(Trt)-OH; (2S)-5-oxo-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-5-(tritylamino)pentanoic acid; Fmoc-Glutamine(Trt)-OH; Nα-Fmoc-Nγ-Trt-L-glutamine
EINECS	Contact for details

Quality Control

Our Fmoc-Gln(Trt)-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via NMR and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.