Description

4-[[(2,2,2-Trifluoroethyl)Amino]Carbonyl]Benzenesulfonyl Chloride is a high-value sulfonyl chloride derivative, a key synthetic intermediate prized for its reactive benzenesulfonyl chloride group and trifluoroethyl amide moiety. This compound is essential for constructing complex molecules where the introduction of a sulfonamide linkage with a fluorinated side chain is required. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of potential drug candidates, particularly for creating sulfonamide-based molecules with enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in developing new herbicides, fungicides, and insecticides where the trifluoroethyl group can impart favorable properties like lipophilicity and resistance to degradation.
• Material Science: Serves as a monomer or modifying agent in the production of specialty polymers and advanced materials with specific surface properties.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes and affinity labels for studying enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-[[(2,2,2-Trifluoroethyl)Amino]Carbonyl]Benzenesulfonyl Chloride
CAS No.	885460-85-5
Molecular Formula	C9H7ClF3NO3S
Molecular Weight	301.67 g/mol
Synonyms	4-[(2,2,2-Trifluoroethylcarbamoyl)benzenesulfonyl chloride; N-(2,2,2-Trifluoroethyl)-4-(chlorosulfonyl)benzamide; 4-(Chlorosulfonyl)-N-(2,2,2-trifluoroethyl)benzamide; p-[(2,2,2-Trifluoroethyl)aminocarbonyl]benzenesulfonyl chloride; Benzamide, 4-(chlorosulfonyl)-N-(2,2,2-trifluoroethyl)-; 885460-85-5
EINECS	Contact for details

Quality Control

Every batch of 4-[[(2,2,2-Trifluoroethyl)Amino]Carbonyl]Benzenesulfonyl Chloride is manufactured and tested under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee full traceability and compliance with your internal quality systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.