Description

4,6-Dichloro-2-(2-Fluoro-Phenyl)-Quinazoline is a high-purity, advanced pharmaceutical intermediate with a defined heterocyclic structure. This compound is of significant commercial importance for its role as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor research and development. It is primarily needed by R&D laboratories, contract manufacturing organizations (CMOs), and pharmaceutical companies engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of targeted kinase inhibitors and other small-molecule drugs.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry, enabling the exploration of new chemical entities and structure-activity relationships (SAR).
• Contract Synthesis: Supplied to CROs and CMOs for custom synthesis projects and process development for clinical trial materials.
• Academic Research: Used in university and institutional labs for biochemical studies and the development of novel therapeutic pathways.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for cost-effective and robust API manufacturing.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	4,6-Dichloro-2-(2-Fluoro-Phenyl)-Quinazoline
CAS No.	885277-47-4
Molecular Formula	C14H7Cl2FN2
Molecular Weight	293.12 g/mol
Synonyms	2-(2-Fluorophenyl)-4,6-dichloroquinazoline; 4,6-Dichloro-2-(2-fluorophenyl)quinazoline; Quinazoline, 4,6-dichloro-2-(2-fluorophenyl)-; 885277-47-4; 2-(2-Fluorophenyl)-4,6-dichloro-quinazoline; 4,6-Dichloro-2-(o-fluorophenyl)quinazoline
EINECS	Contact for details

Quality Control

Our 4,6-Dichloro-2-(2-Fluoro-Phenyl)-Quinazoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.