Description

4-Chloro-7-Fluoro-2-(4-Methoxy-Phenyl)-Quinazoline is a high-purity, synthetically versatile quinazoline derivative that serves as a critical building block in advanced organic synthesis. Its molecular architecture, featuring halogen and methoxy substituents, makes it an essential intermediate for developing novel active pharmaceutical ingredients (APIs) and functional materials. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the development of kinase inhibitors and other targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new therapeutic targets.
• Chemical Biology Probes: Serves as a core scaffold for developing molecular probes to study enzyme function and cellular signaling pathways.
• Agrochemical Development: Potential intermediate for creating new active ingredients in crop protection products.
• Material Science: Investigated as a building block for organic electronic materials due to its conjugated quinazoline core.

Basic Information

Product Name	4-Chloro-7-Fluoro-2-(4-Methoxy-Phenyl)-Quinazoline
CAS No.	885277-27-0
Molecular Formula	C15H10ClFN2O
Molecular Weight	288.70 g/mol
Synonyms	2-(4-Methoxyphenyl)-4-chloro-7-fluoroquinazoline; 4-Chloro-7-fluoro-2-(4-methoxyphenyl)quinazoline; 4-Chloro-7-fluoro-2-(p-methoxyphenyl)quinazoline; Quinazoline, 4-chloro-7-fluoro-2-(4-methoxyphenyl)-; 885277-27-0; 4-Chloro-7-fluoro-2-(4'-methoxyphenyl)quinazoline
EINECS	Contact for details

Quality Control

Our 4-Chloro-7-Fluoro-2-(4-Methoxy-Phenyl)-Quinazoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, identity confirmation (IR, NMR), and impurity profiling. A Certificate of Analysis (COA) detailing all specifications and test results is supplied with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.