Description

4-Chloro-2-(Methylsulfonyl)-6,7,8,9-Tetrahydro-5H-Pyrimido[4,5-E][1,4]Diazepin-5-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused diazepine-pyrimidine core structure. This compound is of significant commercial importance for its role as a critical building block in the synthesis of novel, potent kinase inhibitors and other targeted therapeutic agents. It is primarily sought after by research institutions, pharmaceutical development companies, and fine chemical manufacturers engaged in oncology and CNS drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of proprietary drug candidates, particularly kinase inhibitors.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Biochemical Tool Compound: Serves as a reference standard or a starting point for developing enzyme assay probes.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.
• Academic Research: Utilized in university laboratories for investigating novel heterocyclic chemistry and reaction pathways.

Basic Information

Product Name	4-Chloro-2-(Methylsulfonyl)-6,7,8,9-Tetrahydro-5H-Pyrimido[4,5-E][1,4]Diazepin-5-One
CAS No.	885270-40-6
Molecular Formula	C10H11ClN4O3S
Molecular Weight	302.73 g/mol
Synonyms	4-Chloro-2-(methylsulfonyl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-e][1,4]diazepin-5-one; 5H-Pyrimido[4,5-e][1,4]diazepin-5-one, 4-chloro-6,7,8,9-tetrahydro-2-(methylsulfonyl)-; 885270-40-6; 4-Chloro-2-methanesulfonyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-e][1,4]diazepin-5-one; CAS 885270-40-6
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-2-(Methylsulfonyl)-6,7,8,9-Tetrahydro-5H-Pyrimido[4,5-E][1,4]Diazepin-5-One adheres to stringent internal quality standards, ensuring batch-to-batch consistency and high purity suitable for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We are committed to meeting the specific requirements of our clients, including compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to ensure stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.