Description

Fmoc-(R)-2-Amino-3-Hydroxy-3-Methylbutanoic Acid is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected amino group and a chiral tertiary alcohol side chain. This compound is a critical building block for the solid-phase peptide synthesis (SPPS) of peptides containing the unique (R)-2-amino-3-hydroxy-3-methylbutanoic acid residue, enabling the introduction of sterically hindered, hydrophilic motifs. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science who require precise chiral control and high coupling efficiency in peptide assembly.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid monomer for the automated synthesis of complex therapeutic and research peptides.
• Pharmaceutical Intermediates: Used in the research and development of novel peptide-based drugs, including enzyme inhibitors and receptor agonists/antagonists.
• Bioconjugation & Protein Engineering: Serves as a specialty linker or modified amino acid for site-specific protein labeling and engineering.
• Chemical Biology Probes: Incorporated into peptide probes to study protein-protein interactions and enzyme mechanisms.
• Material Science: A precursor for synthesizing specialized peptidomimetics and bio-inspired polymers with tailored properties.

Basic Information

Product Name	Fmoc-(R)-2-Amino-3-Hydroxy-3-Methylbutanoic Acid
CAS No.	884880-39-1
Molecular Formula	C₂₁H₂₃NO₅
Molecular Weight	369.41 g/mol
Synonyms	Fmoc-(R)-Ahb-OH; Fmoc-(R)-2-Amino-3-hydroxy-3-methylbutyric acid; N-(9-Fluorenylmethoxycarbonyl)-(R)-2-amino-3-hydroxy-3-methylbutanoic acid; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxy-3-methylbutanoic acid; Fmoc-D-Ahb-OH; Fmoc-(R)-3-Hydroxy-3-methyl-2-aminobutanoic Acid
EINECS	Contact for details

Quality Control

Our Fmoc-(R)-2-Amino-3-Hydroxy-3-Methylbutanoic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.