Description

1-Methyl-3-(Trifluoromethyl)-1H-Pyrazole-5-Sulfonyl Chloride is a high-value, multi-functional sulfonyl chloride building block essential for modern synthetic chemistry. Its core value lies in enabling the efficient introduction of the sulfonamide moiety, a key pharmacophore, into target molecules. This compound is critically needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients, particularly in medicinal chemistry for lead optimization and library synthesis.

Application

• Pharmaceutical Intermediate: A key precursor for synthesizing sulfonamide-based drug candidates, including kinase inhibitors, receptor antagonists, and anti-infective agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that require the sulfonamide functional group for bioactivity.
• Chemical Biology & Proteomics: Serves as a reactive handle for labeling proteins or synthesizing activity-based probes (ABPs) due to its sulfonyl chloride group's reactivity with amines.
• Material Science Research: Employed in the synthesis of functional polymers and advanced materials where the sulfonamide linkage imparts specific chemical or physical properties.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	1-Methyl-3-(Trifluoromethyl)-1H-Pyrazole-5-Sulfonyl Chloride
CAS No.	884340-52-7
Molecular Formula	C5H4F3N2O2SCl
Molecular Weight	248.61 g/mol
Synonyms	5-(Chlorosulfonyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole; 1-Methyl-3-trifluoromethyl-1H-pyrazole-5-sulfonyl chloride; 3-Trifluoromethyl-1-methylpyrazole-5-sulfonyl chloride; 1-Methyl-3-(trifluoromethyl)pyrazole-5-sulfonyl chloride; Pyrazole-5-sulfonyl chloride, 1-methyl-3-(trifluoromethyl)-; 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-sulfonchlorid
EINECS	Contact for details

Quality Control

Our 1-Methyl-3-(Trifluoromethyl)-1H-Pyrazole-5-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.