Description

L-3-Thiolnorvaline is a non-proteinogenic amino acid derivative featuring a thiol group, which makes it a valuable building block for advanced chemical synthesis. This compound is particularly significant for its role as a precursor in the development of novel pharmaceuticals and biochemical research tools. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity chiral intermediates for drug discovery and peptide modification.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly those targeting enzyme inhibition or requiring specific thiol-based reactivity.
• Peptide Modification & Research: Used to introduce thiol functional groups into peptides and proteins for conjugation, labeling, or structural studies.
• Biochemical Probe Development: Serves as a precursor for creating probes and inhibitors that study metabolic pathways involving sulfur-containing amino acids.
• Ligand Synthesis for Catalysis: Employed in the preparation of specialized ligands for asymmetric catalysis and metal complexation.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	L-3-Thiolnorvaline
CAS No.	883942-33-4
Molecular Formula	C5H11NO2S
Molecular Weight	149.21 g/mol
Synonyms	(2S)-2-Amino-3-sulfanylpentanoic acid; L-3-Mercaptonorvaline; (S)-2-Amino-3-mercaptopentanoic acid; 3-Thiol-L-norvaline; H-Cys(Et)-OH; L-3-Thiolnorvaline; L-β-Thionorvaline; L-3-Mercapto-n-valeric acid
EINECS	Contact for details

Quality Control

Our L-3-Thiolnorvaline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing purity, specific rotation, and chromatographic data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and easily oxidized nature. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Specific Rotation	Contact for details
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.