Description

4-(Cyclopropylmethoxy)-3-(Trifluoromethyl)-Benzaldehyde is a high-value, multi-functional aromatic aldehyde building block. This compound matters for its unique trifluoromethyl and cyclopropylmethoxy substituents, which are critical for modulating the lipophilicity, metabolic stability, and biological activity of target molecules. It is primarily needed by pharmaceutical R&D and agrochemical synthesis teams for the development of novel active ingredients, particularly in medicinal chemistry for lead optimization.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel small molecule drug candidates, especially kinase inhibitors and receptor modulators.
• Agrochemical Research: Used in constructing advanced herbicide and fungicide molecules, leveraging the trifluoromethyl group for enhanced efficacy.
• Material Science Precursor: Serves as a starting material for specialty polymers and liquid crystals requiring specific aromatic-aldehyde functionality.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, reductive amination, and heterocycle formation for complex molecule assembly.

Basic Information

Product Name	4-(Cyclopropylmethoxy)-3-(Trifluoromethyl)-Benzaldehyde
CAS No.	883529-03-1
Molecular Formula	C12H11F3O2
Molecular Weight	244.21 g/mol
Synonyms	3-(Trifluoromethyl)-4-(cyclopropylmethoxy)benzaldehyde; 4-(Cyclopropylmethoxy)-3-trifluoromethylbenzaldehyde; 4-Cyclopropylmethoxy-3-trifluoromethylbenzaldehyde; Benzaldehyde, 4-(cyclopropylmethoxy)-3-(trifluoromethyl)-; 883529-03-1; 4-(Cyclopropylmethoxy)-alpha,alpha,α-trifluoro-m-tolualdehyde
EINECS	Contact for details

Quality Control

Our 4-(Cyclopropylmethoxy)-3-(Trifluoromethyl)-Benzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, well-ventilated place. Keep away from oxidizing agents. Due to its sensitivity, minimize exposure to air and moisture during handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.