Description

[2-[(tert-Butoxycarbonyl)Amino]Pyrimidin-5-Yl]Boronic Acid is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex heterocyclic scaffolds. It is primarily utilized by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used to construct pyrimidine-based active ingredients for crop protection products.
• Material Science Research: Employed in the development of organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology: Acts as a versatile handle for bioconjugation and the development of chemical probes.
• Process Chemistry: Serves as a reliable building block for scaling up the production of complex molecules under GMP conditions.
• Academic Research: A valuable reagent for methodological development in organic synthesis and catalysis studies.

Basic Information

Product Name	[2-[(tert-Butoxycarbonyl)Amino]Pyrimidin-5-Yl]Boronic Acid
CAS No.	883231-25-2
Molecular Formula	C9H14BN3O4
Molecular Weight	239.04 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-Boc-pyrimidin-2-amine; 2-[(tert-Butoxycarbonyl)amino]-5-pyrimidinylboronic acid; N-Boc-2-amino-5-pyrimidineboronic acid; 2-(Boc-amino)pyrimidine-5-boronic acid; BOC-2-APB; tert-Butyl [5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl]carbamate (Pinacol Ester); 2-Amino-5-boronopyrimidine, N-Boc protected
EINECS	Contact for details

Quality Control

Our [2-[(tert-Butoxycarbonyl)Amino]Pyrimidin-5-Yl]Boronic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) are available for every batch upon request, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry, cool place. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air and moisture should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.