Description

5-Bromo-2-Pyrazol-1-Yl-Pyrimidine is a high-value heterocyclic building block featuring a bromine substituent and a pyrazole-pyrimidine core structure. This compound is essential for facilitating efficient cross-coupling reactions and serving as a versatile scaffold in medicinal chemistry research. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of novel active pharmaceutical ingredients (APIs) and agrochemical intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other small-molecule drug candidates targeting various therapeutic areas.
• Agrochemical Research: Used as a building block for developing new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science: Serves as a monomer or functional unit in the development of advanced organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology: Employed in the design and synthesis of molecular probes and tool compounds for studying biological pathways.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Sonogashira, and Buchwald-Hartwig amination reactions to create complex molecular architectures.
• Library Synthesis: A valuable scaffold for generating diverse compound libraries in high-throughput screening for drug discovery.

Basic Information

Product Name	5-Bromo-2-Pyrazol-1-Yl-Pyrimidine
CAS No.	883230-94-2
Molecular Formula	C7H5BrN4
Molecular Weight	225.05 g/mol
Synonyms	5-Bromo-2-(1H-pyrazol-1-yl)pyrimidine; 5-Bromo-2-(pyrazol-1-yl)pyrimidine; 2-(1H-Pyrazol-1-yl)-5-bromopyrimidine; Pyrimidine, 5-bromo-2-(1H-pyrazol-1-yl)-; 883230-94-2; 5-Bromo-2-(1-pyrazolyl)pyrimidine; 5-Bromo-2-pyrazol-1-yl-pyrimidine
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Pyrazol-1-Yl-Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and batch-to-batch consistency for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep the container sealed to prevent moisture absorption and contamination. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.