Description

Fmoc-21-Amino-4,7,10,13,16,19-Hexaoxaheneicosanoic Acid CAS NO 882847-34-9 is a specialized, high-purity polyethylene glycol (PEG)-based amino acid derivative, featuring an Fmoc-protected amine and a terminal carboxylic acid. This compound is engineered to introduce a long, flexible, and hydrophilic spacer arm into peptide and protein structures, which is critical for improving solubility, reducing aggregation, and modulating biological activity. It is an essential building block for researchers and manufacturers in pharmaceutical development, bioconjugation, and advanced materials science, where precise molecular design is paramount.

Application

• Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for solid-phase peptide synthesis, used to incorporate a long, hydrophilic PEG linker between peptide domains.
• Bioconjugation and Linker Chemistry: Serves as a heterobifunctional crosslinker for conjugating peptides, proteins, or drugs to other molecules, nanoparticles, or surfaces via its amine and carboxyl groups.
• PEGylation Reagent: Used to PEGylate therapeutic peptides and proteins, enhancing their pharmacokinetic properties, such as increased circulation half-life and reduced immunogenicity.
• Drug Delivery Systems: A functional component in the design of drug-polymer conjugates and advanced delivery vehicles like micelles or liposomes.
• Surface Functionalization: Employed to create hydrophilic, biofunctional coatings on biosensors, diagnostic arrays, and medical implants.
• Research Grade Chemical: Used in academic and industrial R&D for exploring novel biomaterials, protein engineering, and structure-activity relationship (SAR) studies.

Basic Information

Product Name	Fmoc-21-Amino-4,7,10,13,16,19-Hexaoxaheneicosanoic Acid
CAS No.	882847-34-9
Molecular Formula	C₃₆H₅₁NO₁₁
Molecular Weight	685.79 g/mol
Synonyms	Fmoc-N-amido-PEG6-acid; Fmoc-21-amino-4,7,10,13,16,19-hexaoxaheneicosanoic acid; Fmoc-NH-PEG6-COOH; N-α-Fmoc-21-amino-4,7,10,13,16,19-hexaoxaheneicosanoic acid; Fmoc-PEG6-acid; Fmoc-amino-PEG6-acid; 21-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino-4,7,10,13,16,19-hexaoxaheneicosanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-21-Amino-4,7,10,13,16,19-Hexaoxaheneicosanoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.