Description

4-[2-(Fmoc-Amino)Ethoxy]-Benzoic Acid is a high-purity, protected amino acid derivative designed for advanced peptide synthesis and bioconjugation. This compound matters as a critical building block, offering the orthogonal protection of the Fmoc group for precise, sequential assembly in solid-phase peptide synthesis (SPPS). Pharmaceutical researchers, biotechnology companies, and fine chemical manufacturers need it for developing therapeutic peptides, diagnostic probes, and novel biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, stepwise construction of complex peptide sequences using Fmoc chemistry.
• Linker and Spacer Molecule: Used to introduce a benzoic acid moiety and a flexible ethylene glycol spacer for attaching peptides or other molecules to surfaces, polymers, or carrier proteins.
• Bioconjugation Reagent: Facilitates the covalent attachment of peptides to antibodies, nanoparticles, or other biomolecules for targeted drug delivery and diagnostic applications.
• Combinatorial Chemistry: Serves as a versatile scaffold in the generation of diverse chemical libraries for high-throughput screening in drug discovery.
• Research & Development: Essential for academic and industrial R&D focused on novel peptide-based therapeutics, including hormone analogs and enzyme inhibitors.
• Production of Custom Peptides: Used by CROs and CDMOs in the contract manufacturing of bespoke peptides for clinical and commercial supply.

Basic Information

Product Name	4-[2-(Fmoc-Amino)Ethoxy]-Benzoic Acid
CAS No.	882847-29-2
Molecular Formula	C24H21NO5
Molecular Weight	403.43 g/mol
Synonyms	Fmoc-NH-PEG1-BA; 4-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethoxy)benzoic acid; 2-[2-(Fmoc-amino)ethoxy]benzoic acid (common misnomer); N-Fmoc-2-aminoethoxybenzoic acid; Fmoc-8-Amino-3,6-dioxaoctanoic Acid related linker; Benzoic acid, 4-[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethoxy]-; Fmoc protected PEGylated benzoic acid linker; 4-(2-(Fmoc-amino)ethoxy)benzoic Acid
EINECS	Contact for details

Quality Control

Our 4-[2-(Fmoc-Amino)Ethoxy]-Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure compliance with exacting standards for peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.