Description

Fmoc-2-Aminomethyl-Phenylacetic Acid CAS NO 882847-15-6 is a specialized, high-purity amino acid derivative designed for advanced peptide synthesis. This compound matters as a critical building block for introducing the unique 2-aminomethyl-phenylacetic acid moiety under Fmoc-protection strategies, enabling the construction of complex peptides with specific structural features. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the Fmoc/t-Bu strategy, facilitating the incorporation of a side-chain functionalized phenylalanine analog.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the research and development of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Peptidomimetic Design: Used to create modified peptide backbones and non-natural amino acid residues for enhancing metabolic stability and binding affinity in drug discovery.
• Bioconjugation and Labeling: The reactive amino group, after deprotection, can be utilized for site-specific conjugation with fluorophores, tags, or other molecules.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify novel bioactive compounds.
• Academic and Industrial Research: A valuable tool for studying protein-protein interactions, enzyme substrates, and receptor ligands.

Basic Information

Product Name	Fmoc-2-Aminomethyl-Phenylacetic Acid
CAS No.	882847-15-6
Molecular Formula	C24H21NO5
Molecular Weight	403.43 g/mol
Synonyms	Fmoc-Ampa-OH; N-(9-Fluorenylmethoxycarbonyl)-2-(aminomethyl)phenylacetic Acid; 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]methyl]benzenacetic Acid; Fmoc-2-(Aminomethyl)phenylacetic Acid; Fmoc-AMPAA; (2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]aminomethyl}phenyl)acetic Acid
EINECS	Contact for details

Quality Control

Our Fmoc-2-Aminomethyl-Phenylacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	95.0 - 102.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.