Description

4-Chloro-6-(3,4-Dihydro-1(2H)-Quinolinyl)-5-Pyrimidinamine is a high-purity, advanced pharmaceutical intermediate characterized by its fused quinoline-pyrimidine structure. This compound is of significant value in medicinal chemistry for the research and development of novel therapeutic agents, particularly as a key building block for kinase inhibitors. It is primarily sought by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of targeted small-molecule drugs, especially kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Tool Compound: Used in the development of assay probes to study specific enzyme pathways and biological mechanisms.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing high-value, specialized chemicals.
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic chemistry and drug design methodologies.

Basic Information

Product Name	4-Chloro-6-(3,4-Dihydro-1(2H)-Quinolinyl)-5-Pyrimidinamine
CAS No.	882767-85-3
Molecular Formula	C13H13ClN4
Molecular Weight	260.72 g/mol
Synonyms	4-Chloro-6-(1,2,3,4-tetrahydroquinolin-1-yl)pyrimidin-5-amine; 5-Pyrimidinamine, 4-chloro-6-(3,4-dihydro-1(2H)-quinolinyl)-; 4-Chloro-6-(1,2,3,4-tetrahydroquinolin-1-yl)-5-pyrimidinamine; 882767-85-3; 4-Chloro-6-(1,2,3,4-tetrahydroquinolin-1-yl)pyrimidin-5-amine; 4-Chloro-6-(3,4-dihydro-2H-quinolin-1-yl)pyrimidin-5-amine
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-6-(3,4-Dihydro-1(2H)-Quinolinyl)-5-Pyrimidinamine adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability. The material is manufactured under controlled conditions and undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and MS. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.