Description

3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-4-(Trifluoromethyl)Benzenamine is a high-purity, advanced pharmaceutical intermediate and building block featuring both a pinacol boronate ester and an aromatic amine functional group. This compound is critical for modern synthetic chemistry, enabling efficient cross-coupling reactions like the Suzuki-Miyaura reaction to construct complex molecular architectures. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring a trifluoromethylphenyl moiety.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group makes it an ideal reagent for palladium-catalyzed cross-coupling with aryl halides, a cornerstone reaction in medicinal and process chemistry.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the CF3 group enhances biological activity and metabolic stability.
• Material Science: Serves as a precursor for organic electronic materials, such as those used in OLEDs and semiconductors, where its structure can influence charge transport properties.
• Chemical Biology & Proteomics: Can be utilized as a tagging or labeling reagent for bioconjugation and probe development due to its reactive amine handle.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis organizations (CSOs) and CROs serving the global life sciences market.

Basic Information

Product Name	3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-4-(Trifluoromethyl)Benzenamine
CAS No.	882679-08-5
Molecular Formula	C13H17BF3NO2
Molecular Weight	287.09 g/mol
Synonyms	4-(Trifluoromethyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; 3-Amino-4-(trifluoromethyl)phenylboronic acid pinacol ester; 4-Trifluoromethyl-3-aminophenylboronic acid pinacol ester; 3-Pinacolatoboryl-4-(trifluoromethyl)aniline; 2-(4-Amino-2-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; [3-Amino-4-(trifluoromethyl)phenyl]boronic acid pinacol ester; CAS 882679-08-5
EINECS	Contact for details

Quality Control

Our 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-4-(Trifluoromethyl)Benzenamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance in GMP and ISO environments for critical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.