Description

6-Bromo-2-iodoquinazoline is a high-value halogenated quinazoline derivative, a crucial building block in modern synthetic organic chemistry. Its unique bifunctional halogen pattern makes it an indispensable intermediate for constructing complex molecular architectures, particularly in pharmaceutical discovery. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other targeted therapeutic agents, leveraging the quinazoline core's bioactivity.
• Agrochemical Research: Used in developing novel herbicides and fungicides, where the halogenated quinazoline structure can confer specific biological activity.
• Material Science: Serves as a building block for organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components in organic semiconductors.
• Cross-Coupling Reactions: The bromine and iodine atoms offer orthogonal reactivity for sequential Suzuki, Stille, or Buchwald-Hartwig amination reactions, enabling rapid diversification.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and cellular pathways.
• Library Synthesis for Drug Discovery: An essential scaffold for generating diverse compound libraries in high-throughput screening campaigns.

Basic Information

Product Name	6-Bromo-2-iodoquinazoline
CAS No.	882670-93-1
Molecular Formula	C8H4BrIN2
Molecular Weight	334.94 g/mol
Synonyms	2-Iodo-6-bromoquinazoline; Quinazoline, 6-bromo-2-iodo-; 6-Bromo-2-iodo-quinazoline; 882670-93-1; AKOS015903623; BRN 12522084; LS-192430; ZINC000253909996
EINECS	Contact for details

Quality Control

Our 6-Bromo-2-iodoquinazoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR (1H, 13C) and mass spectrometry for structural confirmation, and residual solvent analysis to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent high quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Due to its light-sensitive nature, the container should be amber-colored or stored in dark conditions. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.