Description

N,n-Dibenzyl-6-Chloro-5-Nitropyrimidine-4-Amine is a high-purity, advanced pharmaceutical intermediate characterized by its specific pyrimidine core structure. This compound is of significant value in medicinal chemistry for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in research targeting kinase inhibitors and other therapeutic agents. It is primarily needed by R&D laboratories, process development chemists, and manufacturers in the global pharmaceutical and biotechnology sectors.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potential drug candidates, especially those with a pyrimidine scaffold.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs for developing new therapeutic molecules.
• Kinase Inhibitor Development: Serves as a core precursor in the research and synthesis of compounds designed to modulate kinase activity.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of complex APIs.
• Chemical Reference Standard: Can be utilized as an analytical standard for quality control and method development in pharmaceutical analysis.
• Academic & Institutional Research: Used in universities and research institutes for exploratory synthetic chemistry and biochemical studies.

Basic Information

Product Name	N,n-Dibenzyl-6-Chloro-5-Nitropyrimidine-4-Amine
CAS No.	882272-97-1
Molecular Formula	C18H15ClN4O2
Molecular Weight	354.79 g/mol
Synonyms	6-Chloro-N,N-dibenzyl-5-nitropyrimidin-4-amine; 4-Amino-6-chloro-N,N-dibenzyl-5-nitropyrimidine; N,N-Dibenzyl-6-chloro-5-nitro-4-pyrimidinamine; 882272-97-1; 6-Chloro-5-nitro-N,N-dibenzylpyrimidin-4-amine
EINECS	Contact for details

Quality Control

Our N,n-Dibenzyl-6-Chloro-5-Nitropyrimidine-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from incompatible materials. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.