Description

n-Fmoc-(S)-3-(Methylamino)Butanoic Acid is a high-purity, chiral amino acid derivative protected with a fluorenylmethyloxycarbonyl (Fmoc) group. This compound serves as a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled introduction of a modified β-amino acid moiety into peptide chains. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel peptide-based therapeutics, diagnostics, and biochemical probes. The product is supplied with a guaranteed high level of purity to ensure optimal coupling efficiency and yield in sensitive synthetic applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the automated synthesis of complex peptides.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs) for peptide drugs.
• Bioconjugation: Facilitates the site-specific modification of peptides and proteins for drug delivery systems or diagnostic agents.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Industrial Research: A vital reagent for studying peptide structure-activity relationships (SAR) and developing novel biomolecules.
• Synthesis of Peptidomimetics: Used to incorporate non-natural amino acid structures that mimic natural peptides with enhanced stability or activity.

Basic Information

Product Name	n-Fmoc-(S)-3-(Methylamino)Butanoic Acid
CAS No.	882183-85-9
Molecular Formula	C₂₁H₂₃NO₄
Molecular Weight	353.41 g/mol
Synonyms	Fmoc-β-homoalanine(N-Me); (S)-3-[(9H-Fluoren-9-ylmethoxy)carbonyl(methyl)amino]butanoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-β-homoalanine; Fmoc-N-methyl-β-homoalanine; N-Fmoc-N-methyl-L-β-homoalanine; Nα-Fmoc-Nα-methyl-L-β-homoalanine; Fmoc-Me-β-hAla-OH
EINECS	Contact for details

Quality Control

Our n-Fmoc-(S)-3-(Methylamino)Butanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as chiral purity, HPLC assay, and residual solvent levels are provided and available upon request. Our quality commitment supports compliance in research and cGMP-grade pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-isomer)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.