Description

Phrixotoxin 3 is a selective and potent peptide toxin that acts as a voltage-gated sodium channel (NaV) inhibitor. This compound is a critical research tool for neuroscientists and pharmacologists studying ion channel function, pain pathways, and neurological disorders. It is primarily utilized in academic, pharmaceutical, and biotechnology R&D for target validation, electrophysiology studies, and the development of novel therapeutic agents.

Application

• Neuroscience Research: A key pharmacological tool for probing the function and distribution of specific voltage-gated sodium channel subtypes (e.g., NaV1.7, NaV1.3) in neuronal circuits.
• Pain Pathway Analysis: Used in vitro and in vivo to investigate the role of sodium channels in nociception and to validate novel targets for analgesic drug discovery.
• Electrophysiology Studies: Essential for patch-clamp experiments to characterize sodium channel kinetics, inactivation properties, and compound effects.
• Drug Discovery & Development: Serves as a reference standard and screening tool in high-throughput assays for identifying new sodium channel modulators.
• Toxicology & Venom Research: Studied for its mechanism of action as a component of spider venom, contributing to the understanding of venom biodiversity and bioactivity.
• Cell Signaling & Physiology: Employed to dissect the contribution of specific sodium channel isoforms to cellular excitability in various cell types and disease models.

Basic Information

Product Name	Phrixotoxin 3
CAS No.	880886-00-0
Molecular Formula	C172H274N52O49S8
Molecular Weight	~4080.8 g/mol
Synonyms	Phrixotoxin-3; PrTx3; NaV1.7 inhibitor peptide; Voltage-gated sodium channel inhibitor from *Phrixotrichus auratus*; Synthetic spider venom peptide; μ-TRTX-Pa1a (alternative nomenclature); Neurotoxic peptide 3
EINECS	Contact for details

Quality Control

Our Phrixotoxin 3 is produced under stringent conditions to ensure the highest standards of purity and biological activity, suitable for sensitive research applications. Each batch is supported by comprehensive analytical data. Certificates of Analysis (COA) detailing purity, peptide content, mass spectrometry (MS) confirmation, and endotoxin levels are provided to guarantee traceability and consistency for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to prevent repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Molecular Weight	4080.8 ± 2 Da (MALDI-TOF MS)
Biological Activity (IC50)	Specified per batch (Electrophysiology assay)
Endotoxin Level	< 1.0 EU/mg (LAL test)
Solubility	Soluble in aqueous buffers (e.g., PBS, saline)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.