Description

Fmoc-Dl-4-Hydroxyphenylglycine is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound matters as a key building block for introducing the hydroxyphenylglycine moiety into peptide chains, enabling the creation of complex biomolecules with specific structural and functional properties. It is primarily needed by research institutions, pharmaceutical developers, and biotechnology companies engaged in the synthesis of therapeutic peptides, peptidomimetics, and novel chemical entities.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid for the automated, stepwise construction of peptide sequences.
• Pharmaceutical Intermediate: Serves as a critical precursor in the research and development of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation and Probe Development: Used to incorporate the hydroxyphenylglycine residue into peptides for labeling, imaging, or creating targeted drug conjugates.
• Antibiotic Research: A valuable building block for synthesizing analogs of glycopeptide antibiotics, such as vancomycin and teicoplanin.
• Enzyme Inhibitor Design: Employed in the synthesis of peptide inhibitors that target specific proteases or enzymes.
• Material Science: Can be used to create peptide-based polymers or hydrogels with tailored properties.

Basic Information

Product Name	Fmoc-Dl-4-Hydroxyphenylglycine
CAS No.	879500-54-6
Molecular Formula	C₂₃H₁₉NO₅
Molecular Weight	389.40 g/mol
Synonyms	Fmoc-4-Hydroxy-DL-phenylglycine; N-(9-Fluorenylmethoxycarbonyl)-4-hydroxy-DL-phenylglycine; (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(4-hydroxyphenyl)acetic acid; Fmoc-Hpg-OH; Fmoc-DL-4-Hydroxybenzylglycine; N-Fmoc-4-hydroxy-DL-phenylglycine; 4-Hydroxy-DL-phenylglycine, N-Fmoc derivative; Fmoc-4-OH-Phg-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Dl-4-Hydroxyphenylglycine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and chiral analysis to verify the DL-mixture. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.