Description

2,5-Difluoro-4-Methylbenzaldehyde is a versatile fluorinated aromatic aldehyde building block of significant importance in advanced organic synthesis. Its value lies in the strategic positioning of fluorine atoms and the reactive aldehyde group, enabling precise molecular modifications for performance-driven applications. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in fluorine-based drug discovery programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where fluorine incorporation enhances biological activity, metabolic stability, and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a critical building block for synthesizing fluorinated aromatic cores used in liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs) for electronic devices.
• Polymer & Specialty Chemical Modifier: Employed to introduce fluorine and aldehyde functionality into polymer chains or specialty chemicals, altering properties like solubility, thermal stability, and surface energy.
• Cross-Coupling & Functionalization Reactions: The aldehyde group and halogenated ring make it an excellent substrate for Suzuki, Stille, and other cross-coupling reactions, as well as reductive amination and condensation reactions.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new fluorination strategies and constructing complex molecular architectures.

Basic Information

Product Name	2,5-Difluoro-4-Methylbenzaldehyde
CAS No.	879093-07-9
Molecular Formula	C8H6F2O
Molecular Weight	156.13 g/mol
Synonyms	4-Methyl-2,5-difluorobenzaldehyde; 2,5-Difluoro-p-tolualdehyde; 2,5-Difluoro-4-methylbenzenecarboxaldehyde; Benzaldehyde, 2,5-difluoro-4-methyl-; 879093-07-9 (CAS RN)
EINECS	Contact for details

Quality Control

Our 2,5-Difluoro-4-Methylbenzaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is easily oxidized; for long-term storage, consider maintaining under an inert atmosphere such as nitrogen or argon. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.