Description

4-Chloro-2,5-Difluorobenzaldehyde is a versatile fluorinated aromatic aldehyde building block of significant importance in advanced organic synthesis. Its value lies in the strategic positioning of halogen substituents, which facilitate selective functionalization and serve as key intermediates for complex molecular architectures. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluorophenyl or chlorophenyl motifs for drug discovery and development.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the halogenated benzaldehyde core contributes to biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The chlorine atom provides an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create biaryl structures.
• Functional Dye & Pigment Intermediate: Employed in the synthesis of specialized dyes and pigments where fluorine substitution enhances lightfastness and alters color properties.
• Chemical Research & Development: A valuable reagent for academic and industrial research in medicinal chemistry, material science, and methodology development.

Basic Information

Product Name	4-Chloro-2,5-Difluorobenzaldehyde
CAS No.	879093-02-4
Molecular Formula	C7H3ClF2O
Molecular Weight	176.55 g/mol
Synonyms	2,5-Difluoro-4-chlorobenzaldehyde; 4-Chloro-2,5-difluorobenzenecarboxaldehyde; Benzaldehyde, 4-chloro-2,5-difluoro-; 879093-02-4; 4-Chloro-2,5-difluoro benzaldehyde; 4-Chloro-2,5-difluorobenzene-1-carbaldehyde
EINECS	Contact for details

Quality Control

Our 4-Chloro-2,5-Difluorobenzaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere for long-term preservation. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.