Description

Fmoc-Phe-Ser(Psime,Mepro)-Oh is a specialized, orthogonally protected dipeptide building block used in advanced solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over side-chain reactivity during the construction of complex peptides and peptidomimetics. It is primarily utilized by pharmaceutical R&D teams and fine chemical suppliers focused on developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the controlled, sequential assembly of peptide chains, particularly where serine side-chain protection is required.
• Pharmaceutical Research: For the development and scale-up of novel therapeutic peptide candidates targeting metabolic diseases, oncology, and infectious diseases.
• Peptidomimetic Design: Enables the synthesis of modified peptide analogs with enhanced stability, bioavailability, or receptor selectivity.
• Combinatorial Chemistry Libraries: Used to generate diverse arrays of peptide-based compounds for high-throughput screening in drug discovery.
• Bioconjugation: Serves as a precursor for creating peptide-protein or peptide-small molecule conjugates for diagnostic and targeted delivery applications.
• Academic & Institutional Research: A vital reagent for studying peptide structure-activity relationships (SAR) and biochemical mechanisms in university and government laboratories.

Basic Information

Product Name	Fmoc-Phe-Ser(Psime,Mepro)-Oh
CAS No.	878797-01-4
Molecular Formula	C₃₀H₃₂N₂O₇S
Molecular Weight	564.65 g/mol
Synonyms	Fmoc-Phe-Ser(Mepro)-OH; Fmoc-L-Phenylalanyl-O-(2-methyl-2-propanesulfenyl)-L-serine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-phenylalanyl-O-[(2-methyl-2-propanyl)thio]-L-serine; Fmoc-Phenylalanine-Serine(Mepro)-OH; Fmoc-Phe-Ser(ψMe, Mepro)-OH; Fmoc-Phe-Ser(SMep)-OH; Fmoc-Phe-Ser(ψMe,Mepro)-OH; Nα-Fmoc-L-Phenylalanyl-O-(tert-butylsulfenyl)-L-serine
EINECS	Contact for details

Quality Control

Our Fmoc-Phe-Ser(Psime,Mepro)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research and process development. Certificates of Analysis (COA) detailing specifications such as HPLC purity, chiral purity, and residual solvent content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.