Description

2-(Trifluoromethyl)Pyrimidine-4-Carboxylic Acid is a high-value, multi-functional heterocyclic building block characterized by its pyrimidine core and trifluoromethyl group. This compound is essential for medicinal chemistry and agrochemical research, where its unique structure enables the fine-tuning of molecular properties such as lipophilicity, metabolic stability, and binding affinity. It is primarily sought after by R&D and process development teams in the pharmaceutical, agrochemical, and advanced material sectors for synthesizing novel active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral, and anticancer agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyrimidine moiety.
• Material Science: Serves as a precursor for functionalized ligands and monomers in the synthesis of specialty polymers and organic electronic materials.
• Chemical Biology: Employed as a probe or labeling reagent in biochemical research due to its reactive carboxylic acid group.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in CDMO (Contract Development and Manufacturing Organization) facilities.

Basic Information

Product Name	2-(Trifluoromethyl)Pyrimidine-4-Carboxylic Acid
CAS No.	878742-59-7
Molecular Formula	C6H3F3N2O2
Molecular Weight	192.10 g/mol
Synonyms	4-Pyrimidinecarboxylic acid, 2-(trifluoromethyl)-; 2-(Trifluoromethyl)-4-pyrimidinecarboxylic acid; 2-Trifluoromethylpyrimidine-4-carboxylic acid; 2-TFM-Pyrimidine-4-COOH; 878742-59-7; 2-(Trifluoromethyl)pyrimidine-4-carboxylate
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)Pyrimidine-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications and can accommodate custom purity requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.