Description

3-Quinolinecarboxylic Acid, 7-[(3E)-3-(2-Amino-1-Fluoroethylidene)-1-Piperidinyl]-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Methoxy-4-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex molecular architecture designed for targeted activity. This compound is critical for research and development in the synthesis of novel antibacterial agents, particularly within the fluoroquinolone class. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of next-generation antibiotics and other therapeutic molecules.

Application

• Key Intermediate for Novel Antibiotics: Serves as a crucial building block in the research and synthesis of advanced fluoroquinolone and related antibacterial agents.
• Pharmaceutical R&D: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new therapeutic candidates with improved efficacy and safety profiles.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis processes to create complex, high-value molecules for biological testing.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the production of clinical trial materials and niche active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional laboratories studying bacterial resistance mechanisms and novel drug design.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 7-[(3E)-3-(2-Amino-1-Fluoroethylidene)-1-Piperidinyl]-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Methoxy-4-Oxo-
CAS No.	878592-87-1
Molecular Formula	C21H24F2N4O4
Molecular Weight	434.44 g/mol
Synonyms	7-[(3E)-3-(2-Amino-1-fluoroethylidene)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; GSK-2140944 Intermediate; GSK2140944 Precursor; 1-Cyclopropyl-7-[(3E)-3-(2-amino-1-fluoroethylidene)piperidin-1-yl]-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid; (3E)-7-[3-(2-Amino-1-fluoroethylidene)-1-piperidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical research. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.