Description

(1S)-1-(3-Bromophenyl)-2,2,2-Trifluoroethylamine CAS NO 878539-31-2 is a high-purity chiral amine building block featuring a bromophenyl group and a trifluoroethylamine moiety. This compound is of significant value in pharmaceutical and agrochemical research for constructing complex molecules with specific stereochemistry and enhanced metabolic stability. It is primarily needed by R&D chemists and process development scientists in the life sciences sector for applications such as medicinal chemistry, asymmetric synthesis, and the development of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides where the bromine atom and fluorine groups contribute to biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric hydrogenation and carbon-carbon bond-forming reactions.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials that require halogenated aromatic components.
• Chemical Biology Probes: Utilized as a building block for fluorescent tags, enzyme inhibitors, and other molecular probes in biochemical research.
• Process Chemistry & Scale-up: A critical intermediate for optimizing synthetic routes and scaling up the production of candidate drugs from milligram to kilogram quantities.

Basic Information

Product Name	(1S)-1-(3-Bromophenyl)-2,2,2-Trifluoroethylamine
CAS No.	878539-31-2
Molecular Formula	C8H7BrF3N
Molecular Weight	254.05 g/mol
Synonyms	(1S)-1-(3-Bromophenyl)-2,2,2-trifluoroethanamine; (S)-1-(3-Bromophenyl)-2,2,2-trifluoroethylamine; (S)-α-(3-Bromophenyl)-2,2,2-trifluoroethylamine; (S)-3'-Bromo-α,α,α-trifluorophenethylamine; 1-(3-Bromophenyl)-2,2,2-trifluoroethanamine (S-enantiomer); (S)-1-(3-Bromophenyl)-2,2,2-trifluoro-1-ethanamine; CAS 878539-31-2; 3-Bromo-α,α,α-trifluoro-(S)-phenethylamine
EINECS	Contact for details

Quality Control

Our (1S)-1-(3-Bromophenyl)-2,2,2-Trifluoroethylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), enantiomeric excess (typically ≥99% ee), and impurity profile is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.